Oprah Winfrey approach Angelina Jolie for a team work when Oprah launched her Oprah Winfrey Leadership Academy for Girls in South Africa back in 2006.
But Jolie didn't want involve any part of it. One source told Star (via Fox News), "Oprah thought Angelina would jump at the chance but Jolie's refusal apparently made it the last time she'll ask Angelina to help with any of her causes".
Jolie rejected due to personal reasons. One insider believed, "Angelina has never forgiven Oprah for siding with Jennifer Aniston after Brad Pitt split from Jen during the late show".